circRNA basic information
circBase ID: -
Name: hsa_circ_TP63
Synonym: -
Host Gene: hsa-miR-155-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Hep3B, Huh7, MHCC97L, SK-hep1, SNU-387, SMMC7721
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ZBTB18
Associated microRNA: hsa-miR-155-5p
Biological function: knockdown of circTP63 inhibited cell proliferation, migration, invasion, and promoted cell apoptosis of HCC
Molecular mechanism: circTP63 was a sponge of hsa-miR-155-5p to facilitate the ZBTB18 expression
Survival: poor
Supported No.:
 1
Description:

Our data highlight a critical circTP63-miR-155-5p-ZBTB18 regulatory network involved in the HCC progression, gaining mechanistic insights into the function of circRNAs in HCC progression, and providing effective biomarkers and therapeutic targets for HCC treatment.
Other information
Title:

CircTP63 promotes hepatocellular carcinoma progression by sponging miR-155-5p and upregulating ZBTB18.

Journal: Cancer Cell Int
Published: 2021/3/10
PubMed ID: 33685441