circRNA basic information
circBase ID: hsa_circ_0134111
Name: -
Synonym: circ_0134111
Host Gene: hsa-miR-515-5p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: Osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Human chondrocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SOCS1
Associated microRNA: hsa-miR-515-5p
Biological function: IL-1beta-induced chondrocyte apoptosis, inflammatory responses and ECM degradation were alleviated by circ_0134111 knockdown or miR-515-5p restoration.
Molecular mechanism: Circ_0134111 acted as miR-515-5p sponge to regulate miR-515-5p expression, and miR-515-5p deficiency reversed the effects of circ_0134111 knockdown in IL-1beta-induced chondrocytes.
Survival: -
Supported No.:
 2
Description:

Circ_0134111 knockdown alleviated apoptosis, inflammatory responses and ECM degradation in OA cell model by mediating the miR-515-5p-SOCS1 network, hinting that circ_0134111 was involved in OA progression.
Other information
Title:

Circ_0134111 knockdown relieves IL-1beta-induced apoptosis, inflammation and extracellular matrix degradation in human chondrocytes through the circ_0134111-miR-515-5p-SOCS1 network.

Journal: Int Immunopharmacol
Published: 2021/3/9
PubMed ID: 33684877