circRNA basic information
circBase ID: -
Name: hsa_circ_PRKCA
Synonym: -
Host Gene: hsa-miR-384
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NSCLC cells (H1650, H1299, H460, and A549), human bronchial epithelial cell line (16HBE), and 293T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ITGB1
Associated microRNA: hsa-miR-384
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

Curcumin inhibited NSCLC growth through downregulating circ-PRKCA, which regulated ITGB1 expression by adsorbing miR-384. This study provided a new mechanism to understand how curcumin inhibited the progression of NSCLC.
Other information
Title:

Curcumin suppresses the malignancy of non-small cell lung cancer by modulating the circ-PRKCA/miR-384/ITGB1 pathway.

Journal: Biomed Pharmacother
Published: 2021/3/9
PubMed ID: 33684690