circRNA basic information
circBase ID: -
Name: hsa_circ_CSPP1
Synonym: -
Host Gene: hsa-miR-944
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: LoVo, HCT116
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FZD7
Associated microRNA: hsa-miR-944
Biological function: CircCSPP1 knockdown significantly downregulated enhanced doxorubicin sensitivity, suppressed proliferation, migration, invasion, and induced apoptosis in DOX-resistant CRC cells
Molecular mechanism: hsa-miR-944/FZD7 axis
Survival: -
Supported No.:
 3
Description:

Our data indicated that circCSPP1 knockdown inhibited DOX-resistant CRC cell growth and enhanced doxorubicin sensitivity by miR-944/FZD7 axis, providing a potential target for CRC therapy.
Other information
Title:

Circular RNA circCSPP1 knockdown attenuates doxorubicin resistance and suppresses tumor progression of colorectal cancer via miR-944/FZD7 axis.

Journal: Cancer Cell Int
Published: 2021/3/6
PubMed ID: 33663510