circRNA basic information
circBase ID: hsa_circ_0008928
Name: -
Synonym: circ_0008928
Host Gene: hsa-miR-488
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: A549, H1299, H661, SK-MES-1
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HK2
Associated microRNA: hsa-miR-488
Biological function: circ_0008928 silencing improved CDDP sensitivity and attenuated CDDP-induced cell proliferation, migration, invasion, and glycolysis metabolism
Molecular mechanism: Circ_0008928 was a sponge of hsa-miR-488, and hsa-miR-488 bound to HK2 in CDDP-resistant NSCLC cells
Survival: -
Supported No.:
 1
Description:

Circ_0008928 knockdown improved CDDP sensitivity and hindered cell proliferation, migration, invasion, and glycolysis metabolism by miR-488/HK2 axis in CDDP-resistant NSCLC. This finding provides a new mechanism for studying CDDP-resistant therapy in NSCLC.
Other information
Title:

Serum Exosomes-Based Biomarker circ_0008928 Regulates Cisplatin Sensitivity, Tumor Progression, and Glycolysis Metabolism by miR-488/HK2 Axis in Cisplatin-Resistant Nonsmall Cell Lung Carcinoma.

Journal: Cancer Biother Radiopharm
Published: 2021/3/5
PubMed ID: 33661058