circRNA basic information
circBase ID: hsa_circ_0000831
Name: -
Synonym: circ_0000831
Host Gene: hsa-miR-16-5p
 
 
 
Disease basic information
DO ID:
 6713
DO name: cerebrovascular disease
Disease details: stroke
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: mouse microglia cell line (BV-2)
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-16-5p
Biological function: Microglia was exposed to oxygen-glucose deprivation (OGD), where polarization phenotypes and inflammation were assessed. Middle cerebral artery occlusion was performed in mice to mimic ischemic stroke-induced vertigo, where cerebral blood flow, neurological deficits, vertigo degree, infarct area, inflammation and cell apoptosis were assayed in response to ectopic expression and knockdown of circ_0000831, miR-16-5p, and AdipoR2.
Molecular mechanism: circ_0000831 bound to hsa-miR-16-5p and downregulated hsa-miR-16-5p, and AdipoR2 was targeted by hsa-miR-16-5p and increased PPARgamma expression in microglia. Furthermore, circ_0000831, AdipoR2, or PPARgamma overexpression or hsa-miR-16-5p inhibition alleviated neuroinflammation, vertigo, neurological deficit, and cell apoptosis in MCAO mice. Consistently, circ_0000831, AdipoR2, or PPARgamma upregulation or hsa-miR-16-5p downregulation diminished apoptosis and inflammation of OGD-induced microglia.
Survival: -
Supported No.:
 2
Description:

these findings pinpoint the circ_0000831/miR-16-5p/AdipoR2 axis as an essential signaling pathway during ischemia stroke. Thus, the circRNA circ_0000831 may work as a possible target for novel treatment in patients with ischemic stroke.
Other information
Title:

Overexpressing circ_0000831 is sufficient to inhibit neuroinflammation and vertigo in cerebral ischemia through a miR-16-5p-dependent mechanism.

Journal: Exp Neurol
Published: 2022/3/19
PubMed ID: 35300972