circRNA basic information
circBase ID: -
Name: hsa_circ_PCNT
Synonym: circ_63706
Host Gene: -
 
 
 
Disease basic information
DO ID:
 0050902
DO name: medulloblastoma
Disease details: medulloblastoma
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: circ_63706-deleted cells implanted into mice produced smaller tumors, and mice lived longer than parental cell implants. At the molecular level, circ_63706-deleted cells elevated total ceramide and oxidized lipids and reduced total triglyceride.
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

Our study implicates a novel oncogenic circular RNA in the SHH medulloblastoma subgroup and establishes its molecular function and potential as a future therapeutic target.
Other information
Title:

The oncogenic circular RNA circ_63706 is a potential therapeutic target in sonic hedgehog-subtype childhood medulloblastomas.

Journal: Acta Neuropathol Commun
Published: 2023/3/11
PubMed ID: 36899402