circRNA basic information
circBase ID: hsa_circ_0079593
Name: -
Synonym: circ_0079593
Host Gene: hsa-miR-573
 
 
 
Disease basic information
DO ID:
 1909
DO name: melanoma
Disease details: malignant melanoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: A375, SK-MEL-2
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ABHD2
Associated microRNA: hsa-miR-573
Biological function: The knockdown of circ_0079593 suppressed cell proliferation, cell cycle progression, migration, invasion, and enhanced apoptosis in vitro and inhibited tumor growth in vivo
Molecular mechanism: directly targeted hsa-miR-573, and circ_0079593 controlled ABHD2 expression by hsa-miR-573
Survival: -
Supported No.:
 2
Description:

Our findings identified that the knockdown of circ_0079593 suppressed melanoma progression at least partially through targeting the miR-573/ABHD2 axis, providing evidence for developing circ_0079593 as a promising therapeutic target for melanoma treatment.
Other information
Title:

Circular RNA circ_0079593 enhances malignant melanoma progression by the regulation of the miR-573/ABHD2 axis.

Journal: J Dermatol Sci
Published: 2021/3/3
PubMed ID: 33648800