circRNA basic information
circBase ID: -
Name: hsa_circ_CTNNA1
Synonym: -
Host Gene: hsa-miR-363-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CACO2, LOVO, HT29, SW620, SW480
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CXCL5
Associated microRNA: hsa-miR-363-3p
Biological function: Knockdown of circCTNNA1 could inhibit the proliferation, cell cycle, metastasis, and promote the apoptosis of CRC cells
Molecular mechanism: regulating the hsa-miR-363-3p/CXCL5 axis
Survival: -
Supported No.:
 1
Description:

MiR-363-3p could be sponged by circCTNNA1, and the inhibition effect of circCTNNA1 silencing on CRC progression could be reversed by miR-363-3p inhibitor. Moreover, miR-363-3p could interact with CXCL5, and CXCL5 overexpression also could reverse the suppressive effect of miR-363-3p on CRC progression.

Other information
Title:

CircCTNNA1 acts as a ceRNA for miR-363-3p to facilitate the progression of colorectal cancer by promoting CXCL5 expression.

Journal: J Biol Res (Thessalon)
Published: 2021/3/1
PubMed ID: 33640021