circRNA basic information
circBase ID: -
Name: hsa_circ_MMP11
Synonym: -
Host Gene: hsa-miR-625-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MCF-10A; MCF-7;, MDA-MB-231
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ZEB2
Associated microRNA: hsa-miR-625-5p
Biological function: The suppression of circMMP11 or ZEB2 repressed proliferation, migration, and invasion while induced apoptosis of BC cells
Molecular mechanism: CircMMP11 regulated the expression of ZEB2 by targeting hsa-miR-625-5p
Survival: -
Supported No.:
 4
Description:

CircMMP11/miR-625-5p/ZEB2 axis affected proliferation, migration, invasion, and apoptosis of BC cells through the mechanism of competing endogenous RNAs (ceRNA), indicating that circMMP11 was an oncogenic circRNA in BC.
Other information
Title:

CircMMP11 regulates proliferation, migration, invasion, and apoptosis of breast cancer cells through miR-625-5p/ZEB2 axis.

Journal: Cancer Cell Int
Published: 2021/2/27
PubMed ID: 33632213