circRNA basic information
circBase ID: -
Name: hsa_circ_VAPA
Synonym: -
Host Gene: hsa-miR-876-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: H1299, H1975, A549, HCC827
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: WNT5A
Associated microRNA: hsa-miR-876-5p
Biological function: Knockdown of circVAPA had a suppressive effect on cell proliferation, migration, invasion and stemness, and also inhibited tumor growth in vivo
Molecular mechanism: circVAPA acted as a competing endogenous RNA to up-regulate WNT5A by sponging hsa-miR-876-5p
Survival: -
Supported No.:
 2
Description:

CircVAPA promotes aggressive phenotypes of NSCLC cells by the miR-876-5p/WNT5A axis activating Wnt/beta-catenin signaling.
Other information
Title:

CircVAPA exerts oncogenic property in non-small cell lung cancer by the miR-876-5p/WNT5A axis.

Journal: J Gene Med
Published: 2021/2/24
PubMed ID: 33619796