circRNA basic information
circBase ID: -
Name: hsa_circ_SCAP
Synonym: circSCAP
Host Gene: hsa-miR-221-5p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: Atherosclerosis
Species: human
Species details: human
Sample type: cell line
Sample type details: THP-1 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SCAP
Associated microRNA: hsa-miR-221-5p
Biological function: CircSCAP absence suppressed lipid deposition, inflammation, and oxidative stress in ox-LDL-induced THP-1 cells.
Molecular mechanism: MiR-221-5p was a target of circSCAP, and anti-miR-221-5p largely reversed si-circSCAP-induced effects in ox-LDL-induced THP-1 cells.
Survival: -
Supported No.:
 1
Description:

In conclusion, circSCAP facilitated lipid accumulation, inflammation, and oxidative stress in ox-LDL-induced THP-1 macrophages by regulating miR-221-5p/PDE3B axis.
Other information
Title:

CircSCAP Aggravates Oxidized Low-density Lipoprotein-induced Macrophage Injury by Upregulating PDE3B by miR-221-5p in Atherosclerosis.

Journal: J Cardiovasc Pharmacol
Published: 2021/7/30
PubMed ID: 34321402