circRNA basic information
circBase ID: hsa_circ_0109177
Name: hsa_circ_NOTCH3
Synonym: -
Host Gene: hsa-miR-205-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human BLBC cell line (MDA-MB-468)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: KLF12
Associated microRNA: hsa-miR-205-5p
Biological function: promoted the proliferation, migration, invasion and inhibited the apoptosis
Molecular mechanism: circ_NOTCH3 is capable of binding to hsa-miR-205-5p, and upregulating its target gene KLF12, which can be downregulated by hsa-miR-205-5p overexpression and restored by the co-expression of circ_NOTCH3 and miR205-5p.
Survival: -
Supported No.:
 1
Description:

circ_NOTCH3, being an protooncogene and a powerful biomarker, can function as a sponge, compete with miR-205-5p, modulate KLF12 expression, and promote the development and progression of BLBC.
Other information
Title:

circ_NOTCH3 Functions as a Protooncogene Competing With miR-205-5p, Modulating KLF12 Expression and Promoting the Development and Progression of Basal-Like Breast Carcinoma.

Journal: Front Oncol
Published: 2021/2/9
PubMed ID: 33552974