circRNA basic information
circBase ID: -
Name: hsa_circ_NINL
Synonym: -
Host Gene: hsa-miR-921
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MCF-7, BT474, BT-549, MDA-MB-231
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ADAM9
Associated microRNA: hsa-miR-921
Biological function: circNINL could interact with miR-921 and facilitate BC cells malignant process including proliferation acceleration, migration enhancement and apoptosis evasion via sponging miR-921 in vitro.
Molecular mechanism: circNINL could interact with hsa-miR-921 and facilitate BC cells malignant process including proliferation acceleration, migration enhancement and apoptosis evasion via sponging hsa-miR-921 in vitro.
Survival: poor
Supported No.:
 1
Description:

we demonstrated that circNINL could interact with miR-921 and facilitate BC cells malignant process including proliferation acceleration, migration enhancement and apoptosis evasion via sponging miR-921 in vitro. Further investigations revealed that circNINL/miR-921 axis could mediate the expression of ADAM9 which was a direct target of miR-921.
Other information
Title:

Circular RNA circNINL promotes breast cancer progression through activating beta-catenin signaling via miR-921/ADAM9 axis.

Journal: J Biochem
Published: 2021/1/23
PubMed ID: 33479730