circRNA basic information
circBase ID: hsa_circ_0008274
Name: -
Synonym: circ_0008274
Host Gene: hsa-miR-154-3p
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human PTC cell lines (IHH4, TPC1), normal thyroid cells (Nthy-ori 3-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SLC7A11
Associated microRNA: hsa-miR-154-3p
Biological function: The knockdown of circ_0008274 or SLC7A11 enhanced PTC cell apoptosis and repressed cell migration and adhesion in vitro
Molecular mechanism: modulated SLC7A11 expression by acting as a sponge of hsa-miR-154-3p
Survival: poor
Supported No.:
 2
Description:

the knockdown of circ_0008274 repressed PTC malignant progression at least in part through regulating the miR-154-3p/SLC7A11 axis, providing a promising therapeutic opportunity for PTC treatment.
Other information
Title:

Circular RNA circ_0008274 enhances the malignant progression of papillary thyroid carcinoma via modulating solute carrier family 7 member 11 by sponging miR-154-3p.

Journal: Endocr J
Published: 2021/1/22
PubMed ID: 33473055