circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA_103765
Host Gene: hsa-miR-30
 
 
 
Disease basic information
DO ID:
 8778
DO name: Crohn disease
Disease details: Crohn disease
Species: human
Species details: human
Sample type: cell line
Sample type details: peripheral blood mononuclear cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: DLL4
Associated microRNA: hsa-miR-30
Biological function: TNF-¦Á could induce the expression of circRNA_103765, which was cell apoptosis dependent, while silencing of circRNA_103765 could protect human intestinal epithelial cells (IECs) from TNF-¦Á-induced apoptosis.
Molecular mechanism: circRNA_103765 acted as a molecular sponge to adsorb the miR-30 family and impair the negative regulation of Delta-like ligand 4 (DLL4)
Survival: -
Supported No.:
 1
Description:

CircRNA_103765 is a novel important regulator of the pathogenesis of IBD via sponging miR-30 family-mediated DLL4 expression changes. Blockade of circRNA_103765 could serve as a novel approach for the treatment of IBD patients.
Other information
Title:

CircRNA_103765 acts as a proinflammatory factor via sponging miR-30 family in Crohn disease.

Journal: Sci Rep
Published: 2021/1/14
PubMed ID: 33436852