circRNA basic information
circBase ID: -
Name: hsa_circ_ZFR
Synonym: -
Host Gene: hsa-miR-375
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Hep3B, Huh7, MHCC97-H, SNU-398
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGA2
Associated microRNA: hsa-miR-375
Biological function: CircZFR silence inhibited HCC progression by inhibiting cell proliferation, glycolysis and tumor growth and promoting apoptosis
Molecular mechanism: acted as a molecular sponge of hsa-miR-375 to regulate HMGA2 expression
Survival: -
Supported No.:
 4
Description:

Knockdown of circZFR suppressed the progression of HCC by upregulating miR-375 and downregulating HMGA2, providing new insight into the pathogenesis of HCC.
Other information
Title:

Circular RNA circZFR Promotes Hepatocellular Carcinoma Progression by Regulating miR-375/HMGA2 Axis.

Journal: Dig Dis Sci
Published: 2021/1/13
PubMed ID: 33433801