circRNA basic information
circBase ID: -
Name: hsa_circ_DLC1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Huh-7, Hep3B, HepG2, SK-Hep1
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: HuR-MMP1
Associated microRNA: -
Biological function: inhibited the proliferation and motility of hepatoma cells
Molecular mechanism: bind to RNA-binding protein HuR, which subsequently reduced the interaction between HuR and MMP1 mRNAs, and thus inhibited the expression of MMP1
Survival: -
Supported No.:
 1
Description:

circDLC1, a downstream target of KIAA1429, is a promising prognostic marker for HCC patients, and the circDLC1-HuR-MMP1 axis may serve as a potential therapeutic target for HCC treatment.
Other information
Title:

Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR.

Journal: Theranostics
Published: 2021/1/5
PubMed ID: 33391541