circRNA basic information
circBase ID: hsa_circ_0005526
Name: -
Synonym: Circ_0005526
Host Gene: hsa-miR-142-5p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: chondrocyte cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TCF4
Associated microRNA: hsa-miR-142-5p
Biological function: IL-1beta inhibited cell viability and proliferation but enhanced cell apoptosis and inflammation, then these damages were attenuated after downregulation of circ_0005526.
Molecular mechanism: Circ_0005526 interacted with miR-142-5p, and circ_0005526 knockdown suppressed IL-1beta-induced OA progression through upregulating miR-142-5p.
Survival: -
Supported No.:
 1
Description:

These results unraveled that circ_0005526 promoted IL-1beta-induced chondrocyte injury in OA via suppressing miR-142-5p binding to TCF4.
Other information
Title:

Circ_0005526 contributes to interleukin-1beta-induced chondrocyte injury in osteoarthritis via upregulating transcription factor 4 by interacting with miR-142-5p.

Journal: Bioengineered
Published: 2022/3/25
PubMed ID: 35322736