circRNA basic information
circBase ID: -
Name: hsa_circ_ARRDC3
Synonym: circARRDC3
Host Gene: hsa-miR_375
 
 
 
Disease basic information
DO ID:
 4483
DO name: rhinitis
Disease details: rhinitis
Species: human
Species details: human
Sample type: cell line
Sample type details: nasal epithelial cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KLF4
Associated microRNA: hsa-miR_375
Biological function: circARRDC3 knockdown suppressed the levels of granulocyte_macrophage colony_stimulating factor (GM_CSF) and eotaxin and mucin 5AC (MUC5AC) in IL_13_induced nasal epithelial cells. Moreover, circARRDC3 silencing promoted viability and suppressed apoptosis in IL_13_induced NECs.
Molecular mechanism: circARRDC3 targeted microRNA (miR)_375 and negatively regulated its expression. miR_375 inhibition reversed the effects of circARRDC3 knockdown on GM_CSF, eotaxin and MUC5AC expression levels
Survival: -
Supported No.:
 1
Description:

In conclusion, circARRDC3 contributed to the development of AR by regulating the miR_375/KLF4 axis. These findings may provide novel insights into the pathogenesis of AR.
Other information
Title:

circARRDC3 contributes to interleukin_13__nduced inflammatory cytokine and mucus production in nasal epithelial cells via the miR_375/KLF4 axis.

Journal: Mol Med Rep
Published: 2020/12/15
PubMed ID: 33313951