circRNA basic information
circBase ID: hsa_circ_0003998
Name: -
Synonym: Circ_0003998
Host Gene: hsa-miR-218-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Hep3B, Huh7, HCCLM3
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: EIF5A2
Associated microRNA: hsa-miR-218-5p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 3
Description:

Circ_0003998 knockdown sensitized HCC cell to DOX by regulating miR-218-5p/EIF5A2 axis, indicating new markers of poor response to DOX and potential therapeutic strategies for the chemotherapy of HCC.
Other information
Title:

Circ_0003998 enhances doxorubicin resistance in hepatocellular carcinoma by regulating miR-218-5p/EIF5A2 pathway.

Journal: Diagn Pathol
Published: 2020/12/15
PubMed ID: 33308276