circRNA basic information
circBase ID: hsa_circ_0001445
Name: -
Synonym: circ_0001445
Host Gene: hsa-miRNA-640
 
 
 
Disease basic information
DO ID:
 178
DO name: vascular disease
Disease details: inflammatory
Species: human
Species details: human
Sample type: cell line
Sample type details: HUVECs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miRNA-640
Biological function: Overexpression of Hsa_circ_0001445 promoted cell proliferation, inhibited ox-LDL-induced HUVEC inflammatory response, downregulate the expression of TNF-¦Á, IL-1beta and IL-16, overexpression of Hsa_circ_0001445 inhibited cell apoptosis.
Molecular mechanism: miRNA-640 was confirmed as a direct target of Hsa_circ_0001445, and miRNA-640 mimic reversed the effects of Hsa_circ_0001445 overexpression on ox-LDL-induced HUVECs.
Survival: -
Supported No.:
 1
Description:

Our findings concluded that Hsa_circ_0001445 inhibits ox-LDL-induced HUVEC inflammation, oxidative stress and apoptosis by regulating miRNA-640.
Other information
Title:

Hsa_circ_0001445 inhibits ox-LDL-induced HUVECs inflammation, oxidative stress and apoptosis by regulating miRNA-640.

Journal: Perfusion
Published: 2020/12/11
PubMed ID: 33300444