circRNA basic information
circBase ID: -
Name: hsa_circ_SMYD4
Synonym: -
Host Gene: hsa-miR-584-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SNU-182 (CRL-2235), SNU-387 (CRL-2237), SNU-423 (CRL-2238), Hep3B (HB-8064), PLC/PRF/5 (CRL-8024), SK-Hep1 (HTB-52)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-584-5p
Biological function: inhibited the proliferation, invasion and migration and promoted the apoptosis of HCC cells in vitro, while it inhibited tumor growth, promoted apoptosis-related proteins, and suppressed alpha-fetoprotein (AFP) levels in vivo
Molecular mechanism: used as a miRNA sponge to target hsa-miR-584-5p
Survival: -
Supported No.:
 3
Description:

Up-regulation of circSMYD4 inhibited the proliferation, invasion and migration and promoted the apoptosis of HCC cells in vitro, while it inhibited tumor growth, promoted apoptosis-related proteins, and suppressed alpha-fetoprotein (AFP) levels in vivo. CircSMYD4 could be used as a miRNA sponge to target miR-584-5p. In addition, miR-584-5p overexpression partially reversed the regulatory effect of circSMYD4 on HCC.
Other information
Title:

CircSMYD4 regulates proliferation, migration and apoptosis of hepatocellular carcinoma cells by sponging miR-584-5p.

Journal: Cancer Cell Int
Published: 2020/12/10
PubMed ID: 33292243