circRNA basic information
circBase ID: -
Name: hsa_circ_PRMT5
Synonym: -
Host Gene: hsa-miR-509-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MDA-MB-231, SKBR3, MCF-7
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TCF7L2
Associated microRNA: hsa-miR-509-3p
Biological function: knockdown of circ-PRMT5 suppresses cell proliferation and angiogenesis and increases cell apoptosis in breast cancer
Molecular mechanism: up-regulates TCF7L2 expression by acting as a hsa-miR-509-3p sponge
Survival: poor
Supported No.:
 2
Description:

Functionally, knockdown of circ-PRMT5 suppresses cell proliferation and angiogenesis and increases cell apoptosis in breast cancer. Mechanistically, we identified that circ-PRMT5 up-regulates TCF7L2 expression by acting as a miR-509-3p sponge. The negative expression correlation between miR-509-3p and circ-PRMT5 or TCF7L2 in clinical tissues was further demonstrated.
Other information
Title:

Circ-PRMT5 promotes breast cancer by the miR-509-3p/TCF7L2 axis activating the PI3K/AKT pathway.

Journal: J Gene Med
Published: 2020/12/6
PubMed ID: 33277756