circRNA basic information
circBase ID: -
Name: hsa_circ_SOD2
Synonym: -
Host Gene: hsa-miR-502-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HEPG2, HUH7, SK-HEP1, HEP3B
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: DNMT3a/JAK2/STAT3
Associated microRNA: hsa-miR-502-5p
Biological function: induced epigenetic alteration drives hepatocellular carcinoma progression
Molecular mechanism: activating JAK2/STAT3 signaling pathway
Survival: -
Supported No.:
 3
Description:

The novel signaling axis circSOD2/miR-502-5p/DNMT3a/JAK2/STAT3/circSOD2 provides a better understanding of HCC tumorigenesis. The molecular mechanism underlying this signaling axis offers new prevention and treatment of HCC.
Other information
Title:

CircSOD2 induced epigenetic alteration drives hepatocellular carcinoma progression through activating JAK2/STAT3 signaling pathway.

Journal: J Exp Clin Cancer Res
Published: 2020/11/26
PubMed ID: 33234142