circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: ciRS-7, CDR1as
Host Gene: hsa-miR-7-5p
 
 
 
Disease basic information
DO ID:
 6432
DO name: pulmonary hypertension
Disease details: pulmonary hypertension
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HPASMCs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CAMK2D and CNN3
Associated microRNA: hsa-miR-7-5p
Biological function: Upregulating CAMK2D and CNN3 via Sponging miR-7-5p
Molecular mechanism: Promotes Pulmonary Artery Smooth Muscle Cell Calcification
Survival: -
Supported No.:
 1
Description:

the CDR1as/miR-7-5p/CNN3 and CAMK2D regulatory axis mediates HPASMC osteoblastic differentiation and calcification induced by hypoxia. This evidence reveals an approach to the treatment of PH.
Other information
Title:

circRNA CDR1as Promotes Pulmonary Artery Smooth Muscle Cell Calcification by Upregulating CAMK2D and CNN3 via Sponging miR-7-5p.

Journal: Mol Ther Nucleic Acids
Published: 2020/11/25
PubMed ID: 33230455