circRNA basic information
circBase ID: -
Name: hsa_circ_DLGAP4
Synonym: -
Host Gene: hsa-miR-143
 
 
 
Disease basic information
DO ID:
 557
DO name: kidney disease
Disease details: diabetic kidney disease
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ERBB3/NF-kappaB/MMP-2
Associated microRNA: hsa-miR-143
Biological function: promotes diabetic kidney disease progression
Molecular mechanism: sponging hsa-miR-143 and targeting ERBB3/NF-kappaB/MMP-2 axis
Survival: -
Supported No.:
 1
Description:

overexpression of circ_DLGAP4 markedly promoted DKD progression in vivo via modulating miR-143/ERBB3/NF-kappaB/MMP-2. In conclusion, we indicated that exosomal circ_DLGAP4 could prove a novel insight for DKD development.
Other information
Title:

Exosomal circ_DLGAP4 promotes diabetic kidney disease progression by sponging miR-143 and targeting ERBB3/NF-kappaB/MMP-2 axis.

Journal: Cell Death Dis
Published: 2020/11/25
PubMed ID: 33230102