circRNA basic information
circBase ID: -
Name: hsa_circ_LRIG3
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SNU-423, HepG2, Hep3B, Huh7, SMMC-7721, MHCC-97_L
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: EZH2/STAT3
Associated microRNA: -
Biological function: formed a ternary complex with EZH2 and STAT3, facilitating EZH2-induced STAT3 methylation and subsequent phosphorylation, resulting in the activation of STAT3 signaling
Molecular mechanism: promoted HCC cell proliferation, migration, invasion and reduced apoptosis
Survival: poor
Supported No.:
 3
Description:

A novel circular RNA circ-LRIG3 facilitates the malignant progression of hepatocellular carcinoma by modulating the EZH2/STAT3 signaling.
Other information
Title:

A novel circular RNA circ-LRIG3 facilitates the malignant progression of hepatocellular carcinoma by modulating the EZH2/STAT3 signaling.

Journal: J Exp Clin Cancer Res
Published: 2020/11/24
PubMed ID: 33222697