circRNA basic information
circBase ID: -
Name: hsa_circ_TBL1XR1
Synonym: -
Host Gene: hsa-miR-424
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: LoVo, SW620, IEC-6, HCT 116, SW480
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Smad7
Associated microRNA: hsa-miR-424
Biological function: promote the proliferation and metastasis
Molecular mechanism: regulates the expression of Smad7 through hsa-miR-424
Survival: -
Supported No.:
 1
Description:

circTBL1XR1 was highly expressed in colon cancer, and miR-424 was poorly expressed in colon cancer cells. circTBL1XR1 regulates the expression of Smad7 through miR-424, thereby affecting the malignant progression of colorectal cancer.
Other information
Title:

CircTBL1XR1/miR-424 axis regulates Smad7 to promote the proliferation and metastasis of colorectal cancer.

Journal: J Gastrointest Oncol
Published: 2020/11/20
PubMed ID: 33209488