circRNA basic information
circBase ID: -
Name: hsa_circ_SEC31A
Synonym: -
Host Gene: hsa-miR-376a
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: 16HBE, A549, H1299
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SEC31A
Associated microRNA: hsa-miR-376a
Biological function: CircSEC31A knockdown suppressed NSCLC cell migration, invasion, glycolysis and promoted apoptosis
Molecular mechanism: Regulating SEC31A Expression via Sponging hsa-miR-376a
Survival: -
Supported No.:
 1
Description:

Our findings first identified that the knockdown of circSEC31A suppressed NSCLC malignant progression at least partly through modulating SEC31A expression by acting as a miR-376a sponge, providing a novel molecular target of NSCLC therapy.
Other information
Title:

CircSEC31A Promotes the Malignant Progression of Non-Small Cell Lung Cancer Through Regulating SEC31A Expression via Sponging miR-376a.

Journal: Cancer Manag Res
Published: 2020/11/19
PubMed ID: 33204164