circRNA basic information
circBase ID: -
Name: hsa_circ_COG8
Synonym: -
Host Gene: hsa-miR-182-5p
 
 
 
Disease basic information
DO ID:
 90
DO name: degenerative disc disease
Disease details: intervertebral disk degeneration
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: FOXO3
Associated microRNA: hsa-miR-182-5p
Biological function: CircCOG8 Downregulation Contributes to the Compression-Induced Intervertebral Disk Degeneration
Molecular mechanism: circCOG8/hsa-miR-182-5p/FOXO3 pathway
Survival: -
Supported No.:
 1
Description:

the present study revealed that the circCOG8/miR-182-5p/FOXO3 pathway was an important underlying mechanism in the involvement of compression during the IDD progression. Intervention of circCOG8 is a new therapeutic strategy for IDD treatment.
Other information
Title:

CircCOG8 Downregulation Contributes to the Compression-Induced Intervertebral Disk Degeneration by Targeting miR-182-5p and FOXO3.

Journal: Front Cell Dev Biol
Published: 2020/11/17
PubMed ID: 33195225