circRNA basic information
circBase ID: -
Name: hsa_circ_BIRC6
Synonym: -
Host Gene: hsa-miR-4491
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NCI-H460, A549
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Wnt2B/beta-catenin
Associated microRNA: hsa-miR-4491
Biological function: Small interfering RNA (siRNA)-mediated circ-BIRC6 knockdown suppressed cell proliferation, colony formation, migration and invasion, and promoted apoptosis in NCI-H460 and A549 cells
Molecular mechanism: binding to and negatively regulating hsa-miR-4491
Survival: -
Supported No.:
 5
Description:

circ-BIRC6 functions as a critical regulator of proliferation and apoptosis via binding to and negatively regulating miR-4491, suggesting that circ-BIRC6 might be a potential target for treatment of NSCLC.
Other information
Title:

Depletion of circ-BIRC6, a circular RNA, suppresses non-small cell lung cancer progression by targeting miR-4491.

Journal: Biosci Trends
Published: 2020/11/13
PubMed ID: 33177288