circRNA basic information
circBase ID: hsa_circ_0004872
Name: hsa_circ_MAPK1
Synonym: -
Host Gene: hsa-miR-224
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: AGS, BGC-823, SGC-7901
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: Smad4/ADAR1
Associated microRNA: hsa-miR-224
Biological function: inhibited the proliferation, invasion and migration of GC cells
Molecular mechanism: regulating hsa-miR-224/Smad4/ADAR1 successive regulatory circuit
Survival: -
Supported No.:
 2
Description:

hsa_circ_0004872 acted as a tumor suppressor in GC by forming a negative regulatory loop consisting of hsa_circ_0004872/miR-224/Smad4/ADAR1. Thus, hsa_circ_0004872 may serve as a potential biomarker and therapeutic target for GC.
Other information
Title:

Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit.

Journal: Mol Cancer
Published: 2020/11/12
PubMed ID: 33172486