circRNA basic information
circBase ID: -
Name: hsa_circ_TP63
Synonym: -
Host Gene: hsa-miR-873-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: MCF7, DU4475
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FOXM1
Associated microRNA: hsa-miR-873-3p
Biological function: inducing the progression and malignant behaviors of estrogen receptor-positive breast cancer, such as cell proliferation, cell cycle dysregulation, invasion, migration and even tumor growth.
Molecular mechanism: binds to hsa-miR-873-3p and prevents the targeting of FOXM1
Survival: -
Supported No.:
 1
Description:

circTP63 binds to miR-873-3p and prevents the targeting of FOXM1, thus inducing the progression and malignant behaviors of estrogen receptor-positive breast cancer, such as cell proliferation, cell cycle dysregulation, invasion, migration and even tumor growth. CircTP63 might be a potential biomarker or target to treat estrogen receptor-positive breast cancer patients in the future.
Other information
Title:

Circular RNA circTP63 enhances estrogen receptor-positive breast cancer progression and malignant behaviors through the miR-873-3p/FOXM1 axis.

Journal: Anticancer Drugs
Published: 2020/11/3
PubMed ID: 33136699