circRNA basic information
circBase ID: hsa_circ_0007841
Name: -
Synonym: circ_0007841
Host Gene: hsa-miR-129-5p
 
 
 
Disease basic information
DO ID:
 9538
DO name: multiple myeloma
Disease details: multiple myeloma
Species: human
Species details: human
Sample type: cell line
Sample type details: MM OPM2, JJN3 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: JAG1
Associated microRNA: hsa-miR-129-5p
Biological function: Circ_0007841 knockdown inhibited MM cell proliferation, metastasis and chemoresistance
Molecular mechanism: positively regulated JAG1 expression via absorbing hsa-miR-129-5p
Survival: -
Supported No.:
 5
Description:

Circ_0007841 positively regulated JAG1 expression via absorbing miR-129-5p. Circ_0007841 knockdown inhibited MM cell proliferation, metastasis and chemoresistance through modulating miR-129-5p/JAG1 axis, suggesting that circ_0007841 might serve as a potential therapeutic target of MM.. Circ_0007841 knockdown inhibited MM cell proliferation, metastasis and chemoresistance through modulating miR-129-5p/JAG1 axis, suggesting that circ_0007841 might serve as a potential therapeutic target of MM.
Other information
Title:

Depletion of circ_0007841 inhibits multiple myeloma development and BTZ resistance via miR-129-5p/JAG1 axis.

Journal: Cell Cycle
Published: 2020/11/3
PubMed ID: 33131409