circRNA basic information
circBase ID: -
Name: hsa_circ_XPO1
Synonym: -
Host Gene: hsa-miR-23a-3p, hsa-miR-23b-3p, hsa-miR-23c, hsa-miR-130a-5p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: U2OS, HOS, Saos2, MG63
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: XPO1
Associated microRNA: hsa-miR-23a-3p, hsa-miR-23b-3p, hsa-miR-23c, hsa-miR-130a-5p
Biological function: facilitated the growth and invasion and decreased the apoptosis of OS cells
Molecular mechanism: sponge hsa-miR-23a-3p, hsa-miR-23b-3p, hsa-miR-23c, and hsa-miR-130a-5p to regulate XPO1 expression
Survival: poor
Supported No.:
 2
Description:

circ-XPO1 regulated the expression of XPO1 through sponging miRNAs as a competing endogenous (ceRNA), providing the possibility that circ-XPO1 might play as a new therapeutic target for OS.
Other information
Title:

Circ-XPO1 upregulates XPO1 expression by sponging multiple miRNAs to facilitate osteosarcoma cell progression.

Journal: Exp Mol Pathol
Published: 2020/10/23
PubMed ID: 33091396