circRNA basic information
circBase ID: hsa_circ_0000215
Name: -
Synonym: circ_0000215
Host Gene: hsa-miR-495-3p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: A172, U251, U87, SHG-44, LN-18
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CXCR2
Associated microRNA: hsa-miR-495-3p
Biological function: promoted the proliferation, invasion and epithelial-mesenchymal transition (EMT) but inhibited apoptosis of glioma cells
Molecular mechanism: sponging hsa-miR-495-3p
Survival: -
Supported No.:
 1
Description:

miR-495-3p targeted CXCR2 and negatively regulated CXCR2/PI3K/Akt pathway. However, the effects of miR-495-3p were all dampened by overexpression of circ_0000215. CONCLUSION: These data demonstrated that circ_0000215 functions as a competitive endogenous RNA by sponging miR-495-3p, thus accelerating glioma progression through CXCR2 axis.
Other information
Title:

Circ_0000215 Increases the Expression of CXCR2 and Promoted the Progression of Glioma Cells by Sponging miR-495-3p.

Journal: Technol Cancer Res Treat
Published: 2020/10/23
PubMed ID: 33089764