circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: cir-ITCH, circ-ITCH
Host Gene: hsa-miR-615-3p
 
 
 
Disease basic information
DO ID:
 9538
DO name: multiple myeloma
Disease details: multiple myeloma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: U-266, NCI-H929, RPMI 8226
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PRKCD
Associated microRNA: hsa-miR-615-3p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: better
Supported No.:
 1
Description:

circITCH overexpression enhanced the sensitivity of MM cells to BTZ through miR-615-3p/PRKCD axis, providing a novel potential target for combating BTZ resistance in patients with MM.
Other information
Title:

CircRNA ITCH increases bortezomib sensitivity through regulating the miR-615-3p/PRKCD axis in multiple myeloma.

Journal: Life Sci
Published: 2020/10/9
PubMed ID: 33031827