circRNA basic information
circBase ID: hsa_circ_0085539
Name: hsa_circ_PVT1
Synonym: -
Host Gene: hsa-miR-204-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-204-5p
Biological function: promotes the invasion and epithelial-mesenchymal transition
Molecular mechanism: Inhibiting hsa-miR-204-5p
Survival: -
Supported No.:
 4
Description:

Collectively, this study provides the first link between circPVT1 expression and BCa development. We found that circPVT1 was upregulated in BCa, and its upregulation might promote the invasion and EMT of BCa cells by serving as a ceRNA for miR-204-5p. Therefore, circPVT1 might be a potential diagnostic biomarker and therapeutic target for BCa patients.
Other information
Title:

Circular RNA PVT1 promotes the invasion and epithelial-mesenchymal transition of breast cancer cells through serving as a competing endogenous RNA for miR-204-5p.

Journal: Onco Targets Ther
Published: 2020/9/29
PubMed ID: 32982273