circRNA basic information
circBase ID: hsa_circ_0007874
Name: hsa_circ_MTO1
Synonym: cMTO1
Host Gene: hsa-miR-181b-5p
 
 
 
Disease basic information
DO ID:
 409
DO name: liver disease
Disease details: liver fibrosis
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PTEN
Associated microRNA: hsa-miR-181b-5p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

cMTO1 inhibits HSC activation, at least in part, through miR-181b-5p-mediated PTEN expression. Our results also suggest that cMTO1 may be a novel therapeutic target in liver fibrosis.
Other information
Title:

Circular RNA cMTO1 Promotes PTEN Expression Through Sponging miR-181b-5p in Liver Fibrosis.

Journal: Front Cell Dev Biol
Published: 2020/8/28
PubMed ID: 32850833