circRNA basic information
circBase ID: hsa_circ_0002577
Name: hsa_circ_WDR26
Synonym: -
Host Gene: hsa-miR-625-5p
 
 
 
Disease basic information
DO ID:
 1380
DO name: endometrial cancer
Disease details: endometrial cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: EC cell lines (HEC-1-B, AN3-CA, KLE, HEC1-A, Ishikawa), human endometrial endothelial cells (hEEC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IGF1R/PI3K/Akt pathway
Associated microRNA: hsa-miR-625-5p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 4
Description:

circRNA hsa_circ_002577 accelerated EC progression by acting as a miR-625-5p sponge, upregulating IGF1R and activating the PI3K/Akt pathway, suggesting the potential therapeutic use of hsa_circ_002577 in EC treatment.
Other information
Title:

CircRNA hsa_circ_0002577 accelerates endometrial cancer progression through activating IGF1R/PI3K/Akt pathway.

Journal: J Exp Clin Cancer Res
Published: 2020/8/28
PubMed ID: 32847606