circRNA basic information
circBase ID: hsa_circ_0000512
Name: hsa_circ_RPPH1
Synonym: -
Host Gene: hsa-miR-296-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal colon cells (FHC), CRC cell lines (SW480, HCT116, SW620, LoVo)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: RUNX1
Associated microRNA: hsa-miR-296-5p
Biological function: Knockdown of circ_0000512 Inhibits Cell Proliferation and Promotes Apoptosis
Molecular mechanism: Regulating hsa-miR-296-5p/RUNX1 Axis
Survival: -
Supported No.:
 1
Description:

Knockdown of circ_0000512 inhibited cell proliferation and induced apoptosis in CRC cell by regulating miR-296-5p/RUNX1 axis, which might provide a potential therapeutic target for CRC treatment.
Other information
Title:

Knockdown of circ_0000512 Inhibits Cell Proliferation and Promotes Apoptosis in Colorectal Cancer by Regulating miR-296-5p/RUNX1 Axis.

Journal: Onco Targets Ther
Published: 2020/8/22
PubMed ID: 32821119