circRNA basic information
circBase ID: -
Name: hsa_circ_IL4R
Synonym: -
Host Gene: hsa-miR-541-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal liver epithelial cell line (THLE_2), HCC cell lines (HuH_7, HCCLM3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: GPX4
Associated microRNA: hsa-miR-541-3p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

CircIL4R played an oncogenic role in HCC via the miR-541-3p/GPX4 axis in vivo. Our data suggested that circIL4R served for a tumor promoter and ferroptosis inhibitor in HCC by the miR-541-3p/GPX4 network.
Other information
Title:

CircIL4R facilitates the tumorigenesis and inhibits ferroptosis in hepatocellular carcinoma by regulating the miR-541-3p/GPX4 axis.

Journal: Cell Biol Int
Published: 2020/8/19
PubMed ID: 32808701