circRNA basic information
circBase ID: -
Name: hsa_circ_LPAR3
Synonym: -
Host Gene: hsa-miR-375, hsa-miR-433
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human ESCC cell lines (EC109, EC9706, KYSE30, KYSE150), human esophageal epithelial cell line (HET-1A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGB1
Associated microRNA: hsa-miR-375, hsa-miR-433
Biological function: CircLPAR3 was a stable cyclic transcript, mainly located in the cytoplasm, and its knockdown hindered the proliferation, migration and invasion of ESCC cells and inhibited ESCC tumor growth in vivo
Molecular mechanism: sponging hsa-miR-375/hsa-miR-433 to promote HMGB1 expression
Survival: poor
Supported No.:
 2
Description:

CircLPAR3 might play an oncogenic role in ESCC through sponging miR-375/miR-433 to promote HMGB1 expression, which might provide a theoretical basis for circLPAR3 to become a biomarker for ESCC therapy.
Other information
Title:

Circular RNA circLPAR3 Facilitates Esophageal Squamous Cell Carcinoma Progression Through Upregulating HMGB1 via Sponging miR-375/miR-433.

Journal: Onco Targets Ther
Published: 2020/8/18
PubMed ID: 32801782