circRNA basic information
circBase ID: hsa_circ_0007841
Name: hsa_circ_SEC61A1
Synonym: -
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 9538
DO name: multiple myeloma
Disease details: multiple myeloma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MM cell lines (H929, OPM2), normal plasma cell line (nPCs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: BRD4
Associated microRNA: hsa-miR-338-3p
Biological function: promote the proliferation, cell cycle and motility and restrain the apoptosis
Molecular mechanism: sequestering hsa-miR-338-3p to up-regulate the expression of BRD4
Survival: -
Supported No.:
 5
Description:

Circ_0007841 acted as an oncogene to promote the proliferation, cell cycle and motility and restrain the apoptosis of MM cells through sequestering miR-338-3p to up-regulate the expression of BRD4.
Other information
Title:

Circ_0007841 promotes the progression of multiple myeloma through targeting miR-338-3p/BRD4 signaling cascade.

Journal: Cancer Cell Int
Published: 2020/8/13
PubMed ID: 32782441