circRNA basic information
circBase ID: hsa_circ_0000517
Name: hsa_circ_RPPH1
Synonym: -
Host Gene: hsa-miR-326
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: hepatic epithelial cells (THLE-2), HCC cell lines (HCCLM3, Huh7, MHCC97-H)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SMAD6
Associated microRNA: hsa-miR-326
Biological function: Hsa_circ_0000517 down-regulation repressed cell proliferation, colony formation, migration, and invasion, and induced cell cycle arrest in HCC cells in vitro, and constrained tumor growth in vivo
Molecular mechanism: regulating the hsa-miR-326/SMAD6 axis
Survival: -
Supported No.:
 6
Description:

Hsa_circ_0000517 depletion repressed HCC advancement via regulating the miR-326/SMAD6 axis.
Other information
Title:

Circular RNA hsa_circ_0000517 modulates hepatocellular carcinoma advancement via the miR-326/SMAD6 axis.

Journal: Cancer Cell Int
Published: 2020/8/11
PubMed ID: 32774154