circRNA basic information
circBase ID: hsa_circ_0104345
Name: hsa_circ_IQCH
Synonym: -
Host Gene: hsa-miR-145
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MCF-10A, MDA-MB-451, HCC38, BT549, HCC1806, MCF-7, MDA-MB-231, T47D, BT474, SKBR-3, MDA-MB-468
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: DNMT3A
Associated microRNA: hsa-miR-145
Biological function: Knockdown of circIQCH inhibited breast cancer cell proliferation and migration to lung
Molecular mechanism: circIQCH-hsa-miR-145-DNMT3A axis
Survival: -
Supported No.:
 2
Description:

our study demonstrated the pivotal role of circIQCH-miR-145-DNMT3A axis in breast cancer growth and metastasis via the mechanism of competing endogenous RNAs. Thus, circIQCH could be a potential therapeutic target for breast cancer.
Other information
Title:

circIQCH sponges miR-145 to promote breast cancer progression by upregulating DNMT3A expression.

Journal: Aging (Albany NY)
Published: 2020/8/7
PubMed ID: 32756009