circRNA basic information
circBase ID: -
Name: hsa_circ_CPA4
Synonym: -
Host Gene: hsa-let-7
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human NSCLC cell lines (A549, H1299, SK-MES-1, Calu-3), human normal bronchial epithelial cell line (HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PD-L1
Associated microRNA: hsa-let-7
Biological function: knock-down of circ-CPA4 inhibited cell growth, mobility and epithelial-mesenchymal transition (EMT), and promoted cell death in NSCLC cells
Molecular mechanism: downregulating PD-L1 through serving as a RNA sponge for let-7 miRNA
Survival: -
Supported No.:
 2
Description:

circ-CPA4 regulated cell growth, mobility, stemness and drug resistance in NSCLC cells and inactivated CD8(+) T cells in the tumor immune microenvironment through let-7 miRNA/PD-L1 axis.
Other information
Title:

Circular RNA circ-CPA4/ let-7 miRNA/PD-L1 axis regulates cell growth, stemness, drug resistance and immune evasion in non-small cell lung cancer (NSCLC).

Journal: J Exp Clin Cancer Res
Published: 2020/8/5
PubMed ID: 32746878