circRNA basic information
circBase ID: hsa_circ_0023404
Name: hsa_circ_RNF121
Synonym: -
Host Gene: hsa-miR-136
 
 
 
Disease basic information
DO ID:
 3021
DO name: acute kidney failure
Disease details: acute kidney injury
Species: human
Species details: human
Sample type: cell line
Sample type details: HK-2 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IL-6R
Associated microRNA: hsa-miR-136
Biological function: loss of circ_0023404 increased cell growth, repressed apoptosis, reduced inflammatory factors secretion and oxidative stress generation in vitro
Molecular mechanism: sponging hsa-miR-136 and activating IL-6R
Survival: -
Supported No.:
 1
Description:

circ_0023404 contributed to HK-2 cells injury stimulated by H/R via sponging miR-136 and activating IL-6R.
Other information
Title:

Circ_0023404 sponges miR-136 to induce HK-2 cells injury triggered by hypoxia/reoxygenation via up-regulating IL-6R.

Journal: J Cell Mol Med
Published: 2021/5/5
PubMed ID: 33942982