circRNA basic information
circBase ID: hsa_circ_0001588
Name: hsa_circ_HIST1H4E
Synonym: -
Host Gene: hsa-miR-524-3p
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human lung adenocarcinoma cell lines (SPC-A-1, H1975, A549, H1299)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NACC1
Associated microRNA: hsa-miR-524-3p
Biological function: promote the proliferation, migration, and invasion
Molecular mechanism: upregulated the expression of NACC1 by combining with hsa-miR-524-3p
Survival: poor
Supported No.:
 1
Description:

hsa_circ_0001588 upregulated the expression of NACC1 by combining with miR-524-3p to promote the proliferation, migration, and invasion of lung adenocarcinoma cells, suggesting that hsa_circ_0001588 may be an underlying therapeutic target for lung adenocarcinoma.
Other information
Title:

Circular RNA hsa_circ_0001588 promotes the malignant progression of lung adenocarcinoma by modulating miR-524-3p/NACC1 signaling.

Journal: Life Sci
Published: 2020/8/1
PubMed ID: 32735888